Information flow in cells relies on calcium as a key agent in several signalling pathways. Calcium dependent signalling is crucial in nearly every aspect of life - muscle movement, immune reactions, nerve function, light sensing and many such processes. In fact, one could consider any cellular function, and calcium signalling is probably involved in it in some way. Now, researchers from the National Centre for Biological Sciences (NCBS), Bangalore have discovered a new player in calcium signalling pathways - a protein named Septin 7 that functions as a 'molecular brake' to Orai activation.
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